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• CAS 458-37-7 Curcumin

  Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; ) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.

  
  

  
  

  
  

  
  

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Product Introduction:

Product Name: Curcumin

Synonyms: Curcumin, Natural Yellow 3, Diferuloylmethane;5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(e,e)-6-heptadiene-3;5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-6-heptadiene-3;6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(E,E)-1;curcuma;haidr;halad;haldar

CAS: 458-37-7

MF: C21H20O6

MW: 368.38

EINECS: 207-280-5

Product Categories: Diferuloylmethane, Natural Yellow 3, C.I. 75300;phytochemical;Colorants;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;pigment;Miscellaneous Natural Products;Analytical Chemistry;Antioxidant;Natural Plant Extract;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Biochemistry;Indicator (pH);pH Indicators;chemical reagent;pharmaceutical intermediate;Chalcone;Miscellaneous;bc0001;458-37-7

form powder

Colour Index 75300

color orange

Odor Odorless