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• CAS 604-59-1 α-Naphthoflavone

  Uses    The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. α-Naphthoflavone is a flavone that modulates xenobiotic metabolism at several points. It antagonizes AhR, blocking the expression of phase I and II genes at nanomolar concentrations, although it can agonize AhR at higher concentrations (10 μM). α-Naphthoflavone inhibits CYP19 (aromatase), CYP1A1, CYP1A2, and CYP1B1 (IC50s = 500, 60, 6, and 5 nM, respectively), whereas it activates CYP3A4 (Kd = 7.4 μM). Dietary α-naphthoflavone can contribute to carcinogenesis in the presence of synthetic estrogens.[Cayman Chemical]

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Product Introduction:

Product Name:    α-Naphthoflavone

Synonyms:    7,8-BENZOFLAVONE;ALPHA-NAPHTHOFLAVONE;A-NAPHTHOFLAVANONE;A-NAPHTHOFLAVONE;BENZOFLAVONE;NAPHTHOFLAVANONE, A-;NAPHTHOFLAVONE, A-;2-b)pyran-4-one,2-phenyl-4h-naphtho(

CAS:    604-59-1

MF:    C19H12O2

MW:    272.3

EINECS:    210-071-1

Product Categories:    Flavones;Analytical Reagents;Aryl Hydrocarbon Receptor Antagonist;Cancer Research;Chemopreventive Agents;Redox Indicators;Analytical/Chromatography;Benzopyrans;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks;Indicators;Industrial/Fine Chemicals;N;Titration

form     Crystalline Powder or Crystals

color     yellow