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• CAS 37517-28-5 AMIKACIN

  Product Name: AMIKACIN
  

  Synonyms: 1-N-[L(-)-4-AMINO-2-HYDROXY-BUTYRYL]KANAMYCIN A;AMIKACIN;AMIKACIN DIHYDRATE;2-(DiphenylMethoxy)-N,N-(diMethyl-d6)ethylaMine 8-Chlorotheophyllinate-d6;8-Chlorotheophylline-d6 2-(DiphenylMethoxy)-N,N-(diMethyl-d6)ethylaMine;AMosyt-d12;Anautine-d12;AndraMine-d12

  CAS: 37517-28-5

  MF: C22H43N5O13

  MW: 585.6

  EINECS: 253-538-5

  
  

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Product Introduction:

Description Amikacin is made semisynthetically from kanamycin A. Interestingly, the L-hydroxyaminobutyryl amide (HABA) moiety attached to N-3 inhibits adenylation and phosphorylation in the distant amino sugar ring (at C-2′and C-3′), even though the HABA substituent is not where the enzymatic reaction takes place. This effect is attributed to decreased binding to the R factor–mediated enzymes.